0377345 20240111140816.920120607235959.9 6 s. C cav_un_epca*0377344978-1-4577-2072-7IEEE Catalog Number: CFP1251D-CDR74-79TaiyuanIEEE2012 fermentation process penicillin gradient method optimization cav_un_auth*0281469 Pčolka M. CZ cav_un_auth*0101074 Čelikovský Sergej Teorie řízení Department of Control Theory TŘ TR UTIA-B Department of Control Theory Ústav teorie informace a automatizace AV ČR, v. v. i. textový dokument www.ccdc.neu.edu.cn 188 kB GAP103/12/1794 GA ČR CZ cav_un_auth*0283207 A fermentation process is generally defined as a biological process containing the growth of the biomass (bacteria, yeasts) resulting from the consumption of essential substrate supplies (source of carbon, nitrogen, oxygen, etc.). The biomass growth is usually followed by the production of various products from which especially the variety of antibiotics makes the fermentation processes attractive for the industrial utilization. However, the complicated dynamics, high level of uncertainty and nonlinearity and difficult online measurement of the process variables come hand in hand with the attractivity and turn the attempts on optimal control of the fermentation process into a very delicate challenge. To tackle it, the theory of the gradient projection method has been partially adapted and fully implemented by the authors of this paper. Numerical experiments show its significantly better performance than for other known methods. Moreover, these experiments reveal an interesting ”superprofile” visible for long cultivation times. cav_un_auth*0281470 The 24th Chinese Control and Decision Conference (2012 CCDC) Taiyuan 23.05.2012-25.05.2012 CN 2013 BC 2 PR RVO:67985556 http://hdl.handle.net/11104/0209522 2012 textový dokument 188 kB cav_un_epca*0377344 Proceedings of the 24th Chinese Control and Decision (2012 CCDC) IEEE Catalog Number: CFP1251D-CDR 978-1-4577-2072-7 74 79 Taiyuan IEEE 2012