0378632 20240111140817.920120726235959.9 10.1109/CCDC.2012.6244012 6 s. C cav_un_epca*0378928978-1-4577-2073-41229-1234TaiyuanIEEE2012 Fermentation process penicillin gradient method optimization cav_un_auth*0281469 Pčolka M. CZ cav_un_auth*0101074 Čelikovský Sergej Teorie řízení Department of Control Theory TŘ TR UTIA-B Department of Control Theory Ústav teorie informace a automatizace AV ČR, v. v. i. textový dokument 282 kB GAP103/12/1794 GA ČR CZ cav_un_auth*0283207 Since their discovery, fermentation processes have gone along not only with the industrial beverages production and breweries but since the times of Alexander Fleming they have become a crucial part of the health care due to antibiotics production (from which the overwhelming majority of 90% is produced during a fermentation process). However, complicated dynamics and strong nonlinearities cause that the production with the use of linear control methods achieves only suboptimal yields. From the variety of nonlinear approaches, gradient method has proved the ability to handle these issues - nevertheless, its potential in the field of fermentation processes has not been revealed completely. In this paper, two fresh control strategies are introduced and compared - both of them are based on a double-input optimization approach, yet a successful reduction to a single-input optimization task is proposed. cav_un_auth*0282271 The 2012 20th Mediterranean Conference on Control & Automation (MED) Barcelona 03.07.2012-06.07.2012 ES 2013 BC 2 PR RVO:67985556 http://hdl.handle.net/11104/0210054 2012 textový dokument 282 kB cav_un_epca*0378928 Proceedings of Control and Decision Conference (CCDC), 2012 24th Chinese 978-1-4577-2073-4 1229 1234 Taiyuan IEEE 2012