0424718 20240111140844.220140207235959.9 000330827400008 84895787980 10.1007/s00449-013-0929-z 11 s. P cav_un_epca*02577911615-7591371 (2014)71-81Springer Optimal control Nonlinear systems Fermentation process Gradient method optimization Antibiotics production cav_un_auth*0281469 Pčolka M. CZ cav_un_auth*0101074 Čelikovský Sergej Teorie řízení Department of Control Theory TŘ TR UTIA-B Department of Control Theory Ústav teorie informace a automatizace AV ČR, v. v. i. http://library.utia.cas.cz/separaty/2014/TR/celikovsky-0424718.pdf 792 kB GA13-20433S GA ČR CZ cav_un_auth*0292613 Since their discovery, fermentation processes have gone along not only with the industrial beverages production and breweries, but since the times of Alexander Fleming, they have become a crucial part of the health care due to antibiotics production. However, complicated dynamics and strong nonlinearities cause that the production with the use of linear control methods achieves only suboptimal yields. From the variety of nonlinear approaches, gradient method has proved the ability to handle these issues—nevertheless, its potential in the field of fermentation processes has not been revealed completely. This paper describes constant vaporization control strategy based on a double-input optimization approach with a successful reduction to a single-input optimization task. To accomplish this, model structure used in the previous work is modified so that it corresponds with the new optimization strategy. Furthermore, choice of search step is explored and various alternatives are evaluated and compared. 2015 BC 2 4 A 4a 20231122140103.5 RVO:67985556 http://hdl.handle.net/11104/0230906 cav_un_auth*0300364 ČVUT FEL v Praze Department of Control Engineering, Faculty of Electrical Engineering, Czech Technical University in Prague CZ S BIOTECHNOLOGYAPPLIEDMICROBIOLOGY|ENGINEERINGCHEMICAL 0.453 0.699 Q2 32.459 55.069 Q3 Q3 2014 Soubory v repozitáři: celikovsky-0424718.pdf 84895787980 SCOPUS 000330827400008 WOS 792 kB cav_un_epca*0257791 Bioprocess and Biosystems Engineering 1615-7591 1615-7605 Roč. 37 č. 1 2014 71 81 Springer