0480928 20240111140949.520171106235959.9 85033217842 000417001200027 10.1016/j.jfranklin.2017.10.012 24 s. P cav_un_epca*02537790016-003235418 (2017)8529-8551Elsevier Optimal control Bioprocess Optimization cav_un_auth*0281469 Pčolka M. CZ cav_un_auth*0101074 Čelikovský Sergej Teorie řízení Department of Control Theory TŘ TR UTIA-B Department of Control Theory Ústav teorie informace a automatizace AV ČR, v. v. i. http://library.utia.cas.cz/separaty/2018/TR/celikovsky-0480928.pdf 820 KB cav_un_auth*0347203 GA17-04682S GA ČR CZ This paper presents a computationally tractable algorithm focusing on overall optimization of a production process. The proposed algorithm embraces both the input profile and the state initial conditions optimization and consists of three stages: (i) optimization of the input profile with constant initial conditions, (ii) reduction of the input profile complexity and (iii) joint optimization of the input profile parameters and state initial conditions. The newly proposed algorithm is compared with several alternatives on a series of numerical experiments representing penicillin cultivation process. As a part of the evaluation, a broader range of optimization periods is considered and not only the criterion but also the complexity of the provided input profiles is inspected. The obtained encouraging results show the superiority of the newly proposed solution and demonstrate the usefulness of the joint-optimization algorithm. BC 20000 20200 20205 2018 2 4 A hod 4ah 20231122142801.8 RVO:67985556 http://hdl.handle.net/11104/0276583 cav_un_auth*0300364 Department of Control Engineering, Faculty of Electrical Engineering, Czech Technical University in Prague ČVUT FEL v Praze CZ 1 Department of Control Theory UTIA-B 20205 AUTOMATION & CONTROL SYSTEMS S 3+4 Article Automation Control Systems|Engineering Multidisciplinary|Engineering Electrical Electronic|Mathematics Interdisciplinary Applications 3+4 Article Automation Control Systems|Engineering Multidisciplinary|Engineering Electrical Electronic|Mathematics Interdisciplinary Applications 3+4 Article Automation Control Systems|Engineering Multidisciplinary|Engineering Electrical Electronic|Mathematics Interdisciplinary Applications ENGINEERING.MULTIDISCIPLINARY|ENGINEERING.ELECTRICAL&ELECTRONIC|AUTOMATION&CONTROLSYSTEMS|MATHEMATICS.INTERDISCIPLINARYAPPLICATIONS 3.476 0.539 4.1 0.01524 0.875 6933 1.322 2.785 449 Q1 67.38 87.2 Q2 Q1* 1.6 Q1 95.631 2017 Soubory v repozitáři: celikovsky-0480928.pdf 85033217842 SCOPUS PUBMED 000417001200027 WOS 820 KB cav_un_epca*0253779 Journal of the Franklin Institute-Engineering and Applied Mathematics 0016-0032 1879-2693 Roč. 354 č. 18 2017 8529 8551 Elsevier