0497932 20240103221106.020181211235959.9 85058653636 000452196100006 10.1515/msr-2018-0036 10 s. P cav_un_epca*02948901335-8871186 (2018)262-271Sciendo perfusion imaging contrast agents brain tumors DCE-MRI DSC-MRI cav_un_auth*0297599 Macíček Ondřej D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics UPT-D Magnetic Resonance and Cryogenics K Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0277120 Jiřík Radovan D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics UPT-D Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0236760 Mikulka J. CZ cav_un_auth*0312355 Bartoš Michal Zpracování obrazové informace Department of Image Processing ZOI ZOI UTIA-B Department of Image Processing CZ Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0244979 Šprláková A. CZ cav_un_auth*0297600 Keřkovský M. CZ cav_un_auth*0101622 Starčuk jr. Zenon D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics UPT-D Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0101532 Bartušek Karel D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics UPT-D Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0277119 Taxt T. NO cav_un_auth*0338628 GA16-13830S GA ČR CZ cav_un_auth*0303710 LO1212 GA MŠk CZ cav_un_auth*0266369 ED0017/01/01 GA MŠk cav_un_auth*0333008 LM2015062 GA MŠk CZ EF16_013/0001775 GA MŠk CZ cav_un_auth*0362565 Dynamic contrast enhanced MRI (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI) are perfusion imaging techniques used mainly for clinical and preclinical measurement of vessel permeability and capillary blood flow, respectively. It is advantageous to apply both methods to exploit their complementary information about the perfusion status of the tissue. We propose a novel acquisition method that combines advantages of the current simultaneous and sequential acquisition. The proposed method consists of a DCE-MRI acquisition interrupted by DSC-MRI acquisition. A new method for processing of the DCE-MRI data is proposed which takes the interleaved acquisition into account. Analysis of both the DCE- and DSC-MRI data is reformulated so that they are approximated by the same pharmacokinetic model (constrained distributed capillary adiabatic tissue homogeneity model). This provides a straightforward evaluation of the methodology as some of the estimated DCE- and DSC-MRI perfusion parameters should be identical. Evaluation on synthetic data showed an acceptable precision and no apparent bias introduced by the interleaved character of the DCE-MRI acquisition. Intravascular perfusion parameters obtained from clinical glioma data showed a fairly high correlation of blood flow estimates from DCE- and DSC-MRI, however, an unknown scaling factor was still present mainly because of the tissue-specific r*2 relaxivity. The results show validity of the proposed acquisition method. They also indicate that simultaneous processing of both DCE- and DSC-MRI data with joint estimation of some perfusion parameters (included in both DCE- and DSC-MRI) might be possible to increase the reliability of the DCE- and DSC-MRI methods alone. WOS FS 20000 20600 20601 2019 9 UTIA-B 20000 20200 20206 4 A hod 4ah 20231122143641.1 UTIA-B JD RVO:68081731 RVO:67985556 http://hdl.handle.net/11104/0290386 cav_un_auth*0296535 Ústav teorie informace a automatizace AV ČR ÚTIA AV ČR CZ 1 Department of Image Processing UTIA-B 30224 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING S 3+4 Article Instruments Instrumentation INSTRUMENTS&INSTRUMENTATION 1.157 0.306 6.2 0.00059 0.21 542 0.325 0.973 36 Q4 5.433 23.8 Q4 Q3 0.44 Q3 23.77 2018 Soubory v repozitáři: 0497932.pdf 85058653636 SCOPUS PUBMED 000452196100006 WOS cav_un_epca*0294890 Measurement Science Review 1335-8871 1335-8871 Roč. 18 č. 6 2018 262 271 Sciendo