0507813 20240103222440.920190827235959.9 85067856394 000481725200006 10.1016/j.mri.2019.05.024 11 s. P cav_un_epca*02542200730-725X6246-56Elsevier DCE-MRI blind deconvolution arterial input function cav_un_auth*0277120 Jiřík Radovan UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Magnetic Resonance and Cryogenics K Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0277119 Taxt T. NO cav_un_auth*0297599 Macíček Ondřej UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0312355 Bartoš Michal UTIA-B Zpracování obrazové informace Department of Image Processing ZOI ZOI Department of Image Processing CZ Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0306308 Kratochvíla Jiří UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0103934 Souček Karel BFU-R Oddělení cytokinetiky Department of Cytokinetics DC Department of Cytokinetics Biofyzikální ústav AV ČR, v. v. i. cav_un_auth*0297596 Dražanová Eva UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0341263 Krátká Lucie UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0019982 Hampl A. CZ cav_un_auth*0101622 Starčuk jr. Zenon UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. https://www.sciencedirect.com/science/article/pii/S0730725X18306763?via%3Dihub cav_un_auth*0338628 GA16-13830S GA ČR CZ cav_un_auth*0266369 ED0017/01/01 GA MŠk cav_un_auth*0303710 LO1212 GA MŠk CZ cav_un_auth*0362565 EF16_013/0001775 GA MŠk CZ Purpose: One of the main obstacles for reliable quantitative dynamic contrast-enhanced (DCE) MRI is the need for accurate knowledge of the arterial input function (AIF). This is a special challenge for preclinical small animal applications where it is very difficult to measure the AIF without partial volume and flow artifacts. Furthermore, using advanced pharmacokinetic models (allowing estimation of blood flow and permeability-surface area product in addition to the classical perfusion parameters) poses stricter requirements on the accuracy and precision of AIF estimation. This paper addresses small animal DCE-MRI with advanced pharmacokinetic models and presents a method for estimation of the AIF based on blind deconvolution. Methods: A parametric AIF model designed for small animal physiology and use of advanced pharmacokinetic models is proposed. The parameters of the AIF are estimated using multichannel blind deconvolution. Results: Evaluation on simulated data show that for realistic signal to noise ratios blind deconvolution AIF estimation leads to comparable results as the use of the true AIF. Evaluation on real data based on DCE-MRI with two contrast agents of different molecular weights showed a consistence with the known effects of the molecular weight. Conclusion: Multi-channel blind deconvolution using the proposed AIF model specific for small animal DCE-MRI provides reliable perfusion parameter estimates under realistic signal to noise conditions. WOS FS 20000 20600 20602 2020 10 UTIA-B 10000 10200 10201 BFU-R 20000 20600 20602 4 A sml hod 4as 4as 4ah 20231122144212.3 UTIA-B JD BFU-R FS RVO:68081731 RVO:67985556 RVO:68081707 http://hdl.handle.net/11104/0298781 cav_un_auth*0296535 Ústav teorie informace a automatizace AV ČR ÚTIA AV ČR CZ cav_un_auth*0369160 Biofyzikální ústav AV ČR, v. v. i. CZ 1 Magnetic Resonance and Cryogenics UPT-D 30224 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING 1 Department of Image Processing UTIA-B 30224 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING S 3+4 Review Biochemistry Molecular Biology|Microbiology C RADIOLOGY.NUCLEARMEDICINE&MEDICALIMAGING 2.368 0.595 8.2 0.00865 0.726 7430 126 0.792 40.25 2.2 1483 Q2 1.897 262 Q3 51.578 44.4 Q2 Q4 0.8 Q2 44.403 2019 Soubory v repozitáři: 0507813-Rights & Access.html, 0507813-Order Confirmation.html, 0507813.pdf 85067856394 SCOPUS 31150814 PUBMED 000481725200006 WOS cav_un_epca*0254220 Magnetic Resonance Imaging 0730-725X 1873-5894 Roč. 62 OCT 2019 46 56 Elsevier