0543058 20250123093434.420210608235959.9 85111365933 000723653400047 10.1109/PC52310.2021.9447532 6 s. P cav_un_epca*0543019978-1-6654-0329-0278-283PiscatawayIEEE2021PaulenR.FikarM. Mathematical modelling Model reduction Systems biology Biochemical network cav_un_auth*0404313 Papáček Štěpán UTIA-B Teorie řízení Department of Control Theory TŘ TR CZ Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0215855 Lynnyk Volodymyr UTIA-B Teorie řízení Department of Control Theory TŘ TR Department of Control Theory Ústav teorie informace a automatizace AV ČR, v. v. i. 257,87 KB GA19-05872S GA ČR CZ cav_un_auth*0376352 This paper is devoted to mathematical models describing the drug-induced enzyme production networks. Our aim is to develop an enhanced (yet biologically meaningful) model, which can be used for further analysis and optimization of drug delivery. More precisely, we look for an appropriate model reduction method that could be used for further optimization of drug delivery. For both the full and reduced model, we simulate the model output corresponding to measurable quantity, i.e. mRNA fold induction. The comparison of the full system behavior with the reduced model is presented and future prospects are proposed. The method is illustrated by an example. cav_un_auth*0410022 International Conference on Process Control 2021 /23./ 20210601 20210604 Štrbské Pleso SK BC 10000 10100 10102 2022 2 4 A sml 4as 20231122145752.2 PR RVO:67985556 http://hdl.handle.net/11104/0320436 S IEEE COPYRIGHT AND CONSENT FORM 20210419 66 2021 Soubory v repozitáři: papacek-0543058-CopyrightReceipt_PC21_PAPACEK.pdf 85111365933 SCOPUS PUBMED 000723653400047 WOS 257,87 KB cav_un_epca*0543019 Proceedings of the 2021 23rd International Conference on Process Control (PC) 978-1-6654-0329-0 278 283 Piscataway IEEE 2021 IEEE Catalog Number CFP21PCB-USB Paulen R. 340 Fikar M. 340