0552998 20240903170650.220220208235959.9 000752580600008 10.14736/kyb-2021-6-1005 Biochemical network of drug-induced enzyme production: Parameter estimation based on the periodic dosing response measurement 14 s. P cav_un_epca*02971630023-5954Kybernetika576 (2021)1005-1018Ústav teorie informace a automatizace AV ČR, v. v. i. Parameter estimation Dynamical system Systems pharmacology Biochemical network Input-output regulation Fast Fourier transform cav_un_auth*0215855 Lynnyk Volodymyr UTIA-B Teorie řízení Department of Control Theory TŘ TR Department of Control Theory Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0404313 Papáček Štěpán UTIA-B Teorie řízení Department of Control Theory TŘ TR CZ Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0216347 Rehák Branislav UTIA-B Teorie řízení Department of Control Theory TŘ TR Department of Control Theory Ústav teorie informace a automatizace AV ČR, v. v. i. článek odborném periodiku 3.509 kB http://library.utia.cas.cz/separaty/2022/TR/lynnyk-0552998.pdf https://www.kybernetika.cz/content/2021/6/1005/paper.pdf GA19-05872S GA ČR CZ cav_un_auth*0376352 The well-known bottleneck of systems pharmacology, i. e., systems biology applied to pharmacology, refers to the model parameters determination from experimentally measured datasets. This paper represents the development of our earlier studies devoted to inverse (ill-posed) problems of model parameters identification. The key feature of this research is the introduction of control (or periodic forcing by an input signal being a drug intake) of the nonlinear model of drug-induced enzyme production in the form of a system of ordinary differential equations. First, we tested the model features under periodic dosing, and subsequently, we provided an innovative method for a parameter estimation based on the periodic dosing response measurement. A numerical example approved the satisfactory behavior of the proposed algorithm. WOS BC 10000 10100 10102 2022 3 4 A sml 4as 20231122150340.8 RVO:67985556 http://hdl.handle.net/11104/0328317 S Licence Agreement 20220125 3+4 Article Computer Science Cybernetics A COMPUTERSCIENCE.CYBERNETICS 0.793 0.074 14.2 0.00064 0.225 1031 43 0.247 26.21 0.73 166 Q3 0.611 54 Q4 2.1 Q4 Q4 0.14 Q4 2.083 2021 Soubory v repozitáři: lynnyk-0552998-kybernetika-licence.pdf SCOPUS PUBMED 000752580600008 WOS článek odborném periodiku 3.509 kB cav_un_epca*0297163 Kybernetika 0023-5954 Roč. 57 č. 6 2021 1005 1018 Ústav teorie informace a automatizace AV ČR, v. v. i.