0559273 20250218124659.720220720235959.9 85133679431 000844536800079 10.1371/journal.pone.0270801 13 s. cav_un_epca*03100051932-620317Public Library of Science reinfection SARS-COV-2 vaccination cav_un_auth*1103974 Berec Luděk BC-A ENTU - Ekologie Ecology Insect Ecology K Biologické centrum AV ČR, v. v. i. cav_un_auth*0101206 Šmíd Martin UTIA-B Ekonometrie Department of Econometrics E E Department of Econometrics Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0318938 Přibylová L. CZ cav_un_auth*0265570 Májek O. CZ cav_un_auth*0022185 Pavlík T. CZ cav_un_auth*0015207 Jarkovský J. CZ cav_un_auth*0237467 Zajíček Milan UTIA-B Výpočetní Středisko Computer Centre VS VS Department of Image Processing CZ Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0430347 Weiner J. CZ cav_un_auth*0431344 Barusová Tamara UIVT-O Oddělení statistického modelování Department of Statistical Modelling SK Ústav informatiky AV ČR, v. v. i. cav_un_auth*0091778 Trnka J. CZ textový dokument https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270801 Studies demonstrating the waning of post-vaccination and post-infection immunity against covid-19 generally analyzed a limited range of vaccines or subsets of populations. Using Czech national health data from the beginning of the covid-19 pandemic till November 20, 2021 we estimated the risks of reinfection, breakthrough infection, hospitalization and death by a Cox regression adjusted for sex, age, vaccine type and vaccination status. Vaccine effectiveness against infection declined from 87% at 0-2 months after the second dose to 53% at 7-8 months for BNT162b2 vaccine, from 90% at 0-2 months to 65% at 7-8 months for mRNA-1273, and from 83% at 0-2 months to 55% at 5-6 months for the ChAdOx1-S. Effectiveness against hospitalization and deaths declined by about 15% and 10%, respectively, during the first 6-8 months. Boosters (third dose) returned the protection to the levels observed shortly after dose 2. In unvaccinated, previously infected individuals the protection against infection declined from 97% after 2 months to 72% at 18 months. Our results confirm the waning of vaccination-induced immunity against infection and a smaller decline in the protection against hospitalization and death. Boosting restores the original vaccine effectiveness. Post-infection immunity also decreases over time. WOS FN 30000 30300 30302 2023 10 UTIA-B 10000 10100 10103 UIVT-O 10000 10100 10103 2 O 4 4o 4 20250218124652.9 4 20250218124659.7 UTIA-B BB UIVT-O IN RVO:60077344 RVO:67985556 RVO:67985807 https://hdl.handle.net/11104/0333833 1 cav_un_auth*0297789 Jihočeská univerzita v Českých Budějovicích, Přírodovědecká fakulta University of South Bohemia in České Budějovice CZ cav_un_auth*0296488 Masarykova univerzita, Přírodovědecká fakulta PřF MU CZ cav_un_auth*0313796 Masarykova univerzita, Lékařská fakulta MU CZ cav_un_auth*0318544 1. lékařská fakulta, UK Praha 1. LF UK CZ S e0270801 1 Article Multidisciplinary Sciences A MULTIDISCIPLINARYSCIENCES 3.8 0.6 7.3 0.71257 0.946 886919 0.885 3.500 16285 Q2 65.1 Q3 Q3 0.91 Q1 65.1 2022 Soubory v repozitáři: 0559273-oafin.pdf 85133679431 SCOPUS 35802590 PUBMED 000844536800079 WOS textový dokument cav_un_epca*0310005 PLoS ONE 1932-6203 1932-6203 Roč. 17 č. 7 2022 Public Library of Science ONLINE