0578058 20260108152432.720231114235959.9 85175848114 001108929300050 10.1038/s41598-023-45788-8 9 s. E cav_un_epca*03865942045-232213Nature Publishing Group agent-based model covid-19 epidemiological modelling SEIR cav_un_auth*0222657 Brom C. CZ cav_un_auth*0449183 Diviák T. CZ cav_un_auth*0051505 Drbohlav J. CZ cav_un_auth*0363657 Korbel Václav NHU-N Economics Institute Ekonomický ústav AV ČR, v. v. i. cav_un_auth*0106308 Levínský René NHU-N Ekonomický ústav AV ČR, v. v. i. cav_un_auth*0100794 Neruda Roman UIVT-O Oddělení umělé inteligence Department of Artificial Intelligence Department of Machine Learning Ústav informatiky AV ČR, v. v. i. cav_un_auth*0434902 Kadlecová Gabriela UIVT-O Oddělení umělé inteligence Department of Artificial Intelligence CZ Ústav informatiky AV ČR, v. v. i. cav_un_auth*0259020 Šlerka J. CZ cav_un_auth*0101206 Šmíd Martin UTIA-B Ekonometrie Department of Econometrics E E Department of Econometrics Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0091778 Trnka J. CZ K cav_un_auth*0231277 Vidnerová Petra UIVT-O Oddělení umělé inteligence Department of Artificial Intelligence Department of Machine Learning Ústav informatiky AV ČR, v. v. i. https://doi.org/10.1038/s41598-023-45788-8 Rotations of schoolchildren were considered as a non-pharmacological intervention in the COVID-19 pandemic. This study investigates the impact of different rotation and testing schedules. We built an agent-based model of interactions among pupils and teachers based on a survey in an elementary school in Prague, Czechia. This model contains 624 schoolchildren and 55 teachers and about 27 thousands social contacts in 10 layers. The layers reflect different types of contacts (classroom, cafeteria, etc.) in the survey. On this multi-graph structure we run a modified SEIR model of covid-19 infection. The parameters of the model are calibrated on data from the outbreak in the Czech Republic in spring 2020. Weekly rotations of in-class and distance learning are an effective preventative measure in schools reducing the spread of covid-19 by 75–81% . Antigen testing twice a week or PCR once a week significantly reduces infections even when using tests with a lower sensitivity. The structure of social contacts between pupils and teachers strongly influences the transmission. While the density of contact graphs for older pupils is 1.5 times higher than for younger pupils, the teachers’ network is an order of magnitude denser. Teachers moreover act as bridges between groups of children, responsible for 14–18% of infections in the secondary school compared to 8–11% in the primary school. Weekly rotations with regular testing are a highly effective non-pharmacological intervention for the prevention of covid-19 spread in schools and a way to keep schools open during an epidemic. 10000 10200 10201 2024 11 NHU-N 50000 50200 50202 UTIA-B 10000 10100 10103 2 4 O 4o as 20241118143041.8 20250320211905.0 A sml 20260108152432.7 RVO:67985807 RVO:67985556 RVO:67985998 https://hdl.handle.net/11104/0347085 cav_un_auth*0339298 UTIA cav_un_auth*0345048 Národohospodářský ústav AV ČR S 19156 Article Multidisciplinary Sciences A MULTIDISCIPLINARYSCIENCES 4.3 0.8 4.8 0.90728 1.061 734947 347 0.9 48.79 3.89 283942 Q1 3.700 22037 Q1 81.7 Q2 Q2 1.05 Q1 81.7 2023 Soubory v repozitáři: prohlaseni_levinsky.pdf, 0578058-aoa.pdf 85175848114 SCOPUS 37932281 PUBMED 001108929300050 WOS cav_un_epca*0386594 Scientific Reports 2045-2322 2045-2322 Roč. 13 č. 1 2023 Nature Publishing Group