0599237 20250801121213.620241010235959.9 85180171278 001127990500001 10.1002/mrm.29909 19 s. P cav_un_epca*02572070740-3194915 (2024)1803-1821Wiley challenge data analysis DCE-MRI glioblastoma open-science perfusion cav_un_auth*0474049 Shalom E. S. GB Univ Leeds, Sch Phys & Astron, Leeds, England, Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, England cav_un_auth*0041684 Kim H. US Univ Alabama Birmingham, Dept Radiol, Birmingham, AL USA, cav_un_auth*0474050 van Der Heijden R. A. NL Erasmus MC Univ Med Ctr, Dept Radiol & Nucl Med, Rotterdam, Netherlands, Univ Wisconsin, Dept Radiol, Madison, WI USA cav_un_auth*0474051 Ahmed Z. US Corewell Hlth William Beaumont Univ Hosp, Royal Oak, MI USA, cav_un_auth*0384478 Patel R. US Mayo Clin, Dept Radiol, Div Neuroradiol, Scottsdale, AZ USA, cav_un_auth*0474052 Hormuth D. A. US Univ Texas Austin, Oden Inst Computat Engn & Sci, Austin, TX USA, cav_un_auth*0474053 DiCarlo J. C. US Univ Texas Austin, Livestrong Canc Inst, Biomed Imaging Ctr, Austin, TX USA, cav_un_auth*0474054 Yankeelov T. E. US Univ Texas Austin, Dept Biomed Engn, Oden Inst Computat Engn & Sci, Livestrong Canc Inst, Austin, TX USA, Univ Texas Austin, Dept Diagnost Med, Oden Inst Computat Engn & Sci, Livestrong Canc Inst, Austin, TX USA, Univ Texas Austin, Dept Oncol, Oden Inst Computat Engn & Sci, Livestrong Canc Inst, Austin, TX USA, MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX USA cav_un_auth*0474055 Sisco N. J. US Barrow Neurol Inst, Dept Translat Neurosci, Phoenix, AZ USA, cav_un_auth*0474106 Dortch R. D. US cav_un_auth*0474057 Stokes A. M. US Barrow Neurol Inst, Dept Translat Neurosci, Phoenix, AZ USA, cav_un_auth*0474058 Inglese M. IT Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy, Imperial Coll London, Dept Surg & Canc, London, England cav_un_auth*0474059 Grech-Sollars M. GB Imperial Coll London, Dept Surg & Canc, London, England, UCL, Dept Comp Sci, London, England, Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Lysholm Dept Neuroradiol, London, England cav_un_auth*0474060 Toschi N. IT Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy, Harvard Med Sch, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA USA cav_un_auth*0474061 Sahoo P. DE Univ Med Ctr Gottingen, Gottingen, Germany, cav_un_auth*0455746 Singh A. IN Indian Inst Technol Delhi, Ctr Biomed Engn, New Delhi, India, cav_un_auth*0474062 Verma S. K. SG Inst Bioengn & Bioimaging, Singapore, Singapore, cav_un_auth*0474063 Rathore D. K. GB Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England, cav_un_auth*0474064 Kazerouni A. S. US Univ Washington, Dept Radiol, Seattle, WA USA, cav_un_auth*0474065 Partridge S. C. US Univ Washington, Dept Radiol, Seattle, WA USA, cav_un_auth*0474066 LoCastro E. US Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY USA, cav_un_auth*0474067 Paudyal R. US Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY USA, cav_un_auth*0474068 Wolansky I. A. US Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY USA, cav_un_auth*0474069 Shukla-Dave A. US Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY USA, Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY USA cav_un_auth*0474070 Schouten P. NL Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam, Netherlands, cav_un_auth*0474090 Gurney-Champion O. J. NL cav_un_auth*0277120 Jiřík Radovan UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0297599 Macíček Ondřej UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. cav_un_auth*0312355 Bartoš Michal UTIA-B Zpracování obrazové informace Department of Image Processing ZOI ZOI Department of Image Processing CZ H-8495-2014 Ústav teorie informace a automatizace AV ČR, v. v. i. cav_un_auth*0445458 Vitouš Jiří UPT-D D3: Magnetická rezonance a Kryogenika D3: Magnetic Resonance and Cryogenics Ústav přístrojové techniky AV ČR, v. v. i. https://onlinelibrary.wiley.com/doi/10.1002/mrm.29909 Purpose: K-trans has often been proposed as a quantitative imaging biomarker for diagnosis, prognosis, and treatment response assessment for various tumors. None of the many software tools for K-trans quantification are standardized. The ISMRM Open Science Initiative for Perfusion Imaging-Dynamic Contrast-Enhanced (OSIPI-DCE) challenge was designed to benchmark methods to better help the efforts to standardize K-trans measurement. Methods: A framework was created to evaluate K-trans values produced by DCE-MRI analysis pipelines to enable benchmarking. The perfusion MRI community was invited to apply their pipelines for K-trans quantification in glioblastoma from clinical and synthetic patients. Submissions were required to include the entrants' K-trans values, the applied software, and a standard operating procedure. These were evaluated using the proposed OSIPIgold score defined with accuracy, repeatability, and reproducibility components. Results: Across the 10 received submissions, the OSIPIgold score ranged from 28% to 78% with a 59% median. The accuracy, repeatability, and reproducibility scores ranged from 0.54 to 0.92, 0.64 to 0.86, and 0.65 to 1.00, respectively (0-1 = lowest-highest). Manual arterial input function selection markedly affected the reproducibility and showed greater variability in K-trans analysis than automated methods. Furthermore, provision of a detailed standard operating procedure was critical for higher reproducibility. Conclusions: This study reports results from the OSIPI-DCE challenge and highlights the high inter-software variability within K-trans estimation, providing a framework for ongoing benchmarking against the scores presented. Through this challenge, the participating teams were ranked based on the performance of their software tools in the particular setting of this challenge. In a real-world clinical setting, many of these tools may perform differently with different benchmarking methodology. WOS JD 10000 10200 10201 2025 54 UTIA-B 10000 10200 10201 2 4 O hod 4 4oh 4 20250306113604.6 20250306113643.2 UTIA-B JD RVO:68081731 RVO:67985556 https://hdl.handle.net/11104/0356755 cav_un_auth*0315235 University of Leeds GB cav_un_auth*0332435 University of Sheffield GB cav_un_auth*0448624 University of Alabama US cav_un_auth*0474071 Erasmus MC University Medical Center NL cav_un_auth*0331649 University of Wisconsin-Madison, Madison US cav_un_auth*0474072 Corewell Health William Beaumont University Hospital US cav_un_auth*0412593 Mayo Clinic US cav_un_auth*0298546 University of Texas US cav_un_auth*0474073 MD Anderson Cancer Center, Houston US cav_un_auth*0474074 Barrow Neurological Institute US cav_un_auth*0305286 University of Rome Tor Vergata IT cav_un_auth*0333583 Imperial College London GB cav_un_auth*0299485 University College London GB cav_un_auth*0474094 University College London Hospitals NHS Foundation Trust GB cav_un_auth*0334185 Harvard Medical School US cav_un_auth*0474095 University Medical Center Göttingen DE cav_un_auth*0356218 Indian Institute of Technology Delhi IN cav_un_auth*0474096 Institute of Bioengineering and Bioimaging, Singapore SG cav_un_auth*0329698 King's College London GB cav_un_auth*0314778 University of Washington US cav_un_auth*0474097 Memorial Sloan Kettering Cancer Center, New York US cav_un_auth*0298680 University of Amsterdam NL cav_un_auth*0312853 Cancer Center Amsterdam NL cav_un_auth*0411824 Weill Cornell Medical College, New York US cav_un_auth*0298189 New York University AE cav_un_auth*0298197 University of Manchester GB cav_un_auth*0474098 Christie Hospital NHS Trust GB cav_un_auth*0474099 Institute of Cancer Research, London GB cav_un_auth*0474100 Bioxydyn Ltd, Manchester GB cav_un_auth*0474101 Oregon Health & Science Institute GB cav_un_auth*0474102 Medical College of Wisconsin US cav_un_auth*0474103 Fraunhofer Institute for Digital Medicine MEVIS DE cav_un_auth*0298155 University of California US cav_un_auth*0312964 University of Pennsylvania US cav_un_auth*0474104 Children's Hospital of Philadelphia US cav_un_auth*0351028 Tehran University of Medical Sciences IR cav_un_auth*0315235 University of Leeds GB cav_un_auth*0474105 Genentech Inc. US A RADIOLOGY.NUCLEARMEDICINE&MEDICALIMAGING 3.4 0.6 10.9 0.01524 0.805 30699 257 1.161 46.7 3.13 4583 Q1 1.800 499 Q2 73 0.96 Q2 72.5 2024 Soubory v repozitáři: 0599237.pdf MAGNETIC RESONANCE IN MEDICINE 0740-3194 2024 91 5 85180171278 SCOPUS 38115695 PUBMED 001127990500001 WOS cav_un_epca*0257207 Magnetic Resonance in Medicine Roč. 91 č. 5 2024 1803 1821 0740-3194 1522-2594 Wiley