| bibtype |
C -
Conference Paper (international conference)
|
| ARLID |
0542303 |
| utime |
20250123094326.8 |
| mtime |
20210513235959.9 |
| WOS |
000672803500009 |
| DOI |
10.21136/panm.2020.09 |
| title
(primary) (eng) |
REGULATORY NETWORK OF DRUG-INDUCED ENZYME PRODUCTION: PARAMETER ESTIMATION BASED ON THE PERIODIC DOSING RESPONSE MEASUREMENT |
| specification |
| page_count |
9 s. |
| media_type |
P |
|
| serial |
| ARLID |
cav_un_epca*0542457 |
| ISBN |
978-80-85823-71-4 |
| title
|
Programs and Algorithms of Numerical Mathematics. Proceedings of Seminar |
| part_num |
20 |
| page_num |
89-97 |
| publisher |
| place |
Prague |
| name |
Institute of Mathematics CAS |
| year |
2021 |
|
| editor |
|
| editor |
|
| editor |
|
| editor |
|
| editor |
|
| editor |
|
|
| keyword |
Dynamical system |
| keyword |
Regulatory network |
| keyword |
Input-output |
| keyword |
Regulation |
| keyword |
Parameter estimation |
| keyword |
FFT |
| author
(primary) |
| ARLID |
cav_un_auth*0404313 |
| name1 |
Papáček |
| name2 |
Štěpán |
| institution |
UTIA-B |
| full_dept (cz) |
Teorie řízení |
| full_dept (eng) |
Department of Control Theory |
| department (cz) |
TŘ |
| department (eng) |
TR |
| country |
CZ |
| fullinstit |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0215855 |
| name1 |
Lynnyk |
| name2 |
Volodymyr |
| institution |
UTIA-B |
| full_dept (cz) |
Teorie řízení |
| full_dept |
Department of Control Theory |
| department (cz) |
TŘ |
| department |
TR |
| full_dept |
Department of Control Theory |
| fullinstit |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0216347 |
| name1 |
Rehák |
| name2 |
Branislav |
| institution |
UTIA-B |
| full_dept (cz) |
Teorie řízení |
| full_dept |
Department of Control Theory |
| department (cz) |
TŘ |
| department |
TR |
| full_dept |
Department of Control Theory |
| fullinstit |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
| source |
|
| cas_special |
| project |
| project_id |
GA19-05872S |
| agency |
GA ČR |
| country |
CZ |
| ARLID |
cav_un_auth*0376352 |
|
| abstract
(eng) |
The common goal of systems pharmacology, i.e. systems biology applied to the eld of pharmacology, is to rely less on trial and error in designing an input-output systems, e.g. therapeutic schedules. In this paper we present, on the paradigmatic example of a regulatory network of drug-induced enzyme production, the further development of the study published by Duintjer Tebbens et al. (2019) in the Applications of Mathematics. Here, the key feature is that the nonlinear model in form of an ODE system is controlled (or periodically forced) by an input signal being a drug intake. Our aim is to test the model features under both periodic and nonrecurring dosing, and eventually to provide an innovative method for a parameter estimation based on the periodic dosing response measurement. |
| action |
| ARLID |
cav_un_auth*0404327 |
| name |
Programy a algoritmy numericke matematiky 2020 (PANM 2020) |
| dates |
20200621 |
| mrcbC20-s |
20200626 |
| place |
Hejnice |
| country |
CZ |
|
| RIV |
BC |
| FORD0 |
10000 |
| FORD1 |
10100 |
| FORD2 |
10102 |
| reportyear |
2022 |
| num_of_auth |
3 |
| presentation_type |
PR |
| inst_support |
RVO:67985556 |
| permalink |
http://hdl.handle.net/11104/0320101 |
| confidential |
S |
| arlyear |
2021 |
| mrcbU14 |
SCOPUS |
| mrcbU24 |
PUBMED |
| mrcbU34 |
000672803500009 WOS |
| mrcbU56 |
426 |
| mrcbU63 |
cav_un_epca*0542457 Programs and Algorithms of Numerical Mathematics. Proceedings of Seminar 20 Institute of Mathematics CAS 2021 Prague 89 97 978-80-85823-71-4 |
| mrcbU67 |
Chleboun J. 340 |
| mrcbU67 |
Kůs P. 340 |
| mrcbU67 |
Přikryl P. 340 |
| mrcbU67 |
Rozložník M. 340 |
| mrcbU67 |
Segeth K. 340 |
| mrcbU67 |
Šístek J. 340 |
|