| bibtype |
J -
Journal Article
|
| ARLID |
0552998 |
| utime |
20240903170650.2 |
| mtime |
20220208235959.9 |
| WOS |
000752580600008 |
| DOI |
10.14736/kyb-2021-6-1005 |
| title
(primary) (eng) |
Biochemical network of drug-induced enzyme production: Parameter estimation based on the periodic dosing response measurement |
| specification |
| page_count |
14 s. |
| media_type |
P |
|
| serial |
| ARLID |
cav_un_epca*0297163 |
| ISSN |
0023-5954 |
| title
|
Kybernetika |
| volume_id |
57 |
| volume |
6 (2021) |
| page_num |
1005-1018 |
| publisher |
| name |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
|
| keyword |
Parameter estimation |
| keyword |
Dynamical system |
| keyword |
Systems pharmacology |
| keyword |
Biochemical network |
| keyword |
Input-output regulation |
| keyword |
Fast Fourier transform |
| author
(primary) |
| ARLID |
cav_un_auth*0215855 |
| name1 |
Lynnyk |
| name2 |
Volodymyr |
| institution |
UTIA-B |
| full_dept (cz) |
Teorie řízení |
| full_dept (eng) |
Department of Control Theory |
| department (cz) |
TŘ |
| department (eng) |
TR |
| full_dept |
Department of Control Theory |
| fullinstit |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0404313 |
| name1 |
Papáček |
| name2 |
Štěpán |
| institution |
UTIA-B |
| full_dept (cz) |
Teorie řízení |
| full_dept |
Department of Control Theory |
| department (cz) |
TŘ |
| department |
TR |
| country |
CZ |
| fullinstit |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0216347 |
| name1 |
Rehák |
| name2 |
Branislav |
| institution |
UTIA-B |
| full_dept (cz) |
Teorie řízení |
| full_dept |
Department of Control Theory |
| department (cz) |
TŘ |
| department |
TR |
| full_dept |
Department of Control Theory |
| fullinstit |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
| source |
|
| source |
|
| cas_special |
| project |
| project_id |
GA19-05872S |
| agency |
GA ČR |
| country |
CZ |
| ARLID |
cav_un_auth*0376352 |
|
| abstract
(eng) |
The well-known bottleneck of systems pharmacology, i. e., systems biology applied to pharmacology, refers to the model parameters determination from experimentally measured datasets. This paper represents the development of our earlier studies devoted to inverse (ill-posed) problems of model parameters identification. The key feature of this research is the introduction of control (or periodic forcing by an input signal being a drug intake) of the nonlinear model of drug-induced enzyme production in the form of a system of ordinary differential equations. First, we tested the model features under periodic dosing, and subsequently, we provided an innovative method for a parameter estimation based on the periodic dosing response measurement. A numerical example approved the satisfactory behavior of the proposed algorithm.\n |
| result_subspec |
WOS |
| RIV |
BC |
| FORD0 |
10000 |
| FORD1 |
10100 |
| FORD2 |
10102 |
| reportyear |
2022 |
| num_of_auth |
3 |
| mrcbC52 |
4 A sml 4as 20231122150340.8 |
| inst_support |
RVO:67985556 |
| permalink |
http://hdl.handle.net/11104/0328317 |
| confidential |
S |
| contract |
| name |
Licence Agreement |
| date |
20220125 |
|
| mrcbC86 |
3+4 Article Computer Science Cybernetics |
| mrcbC91 |
A |
| mrcbT16-e |
COMPUTERSCIENCECYBERNETICS |
| mrcbT16-j |
0.225 |
| mrcbT16-s |
0.247 |
| mrcbT16-D |
Q4 |
| mrcbT16-E |
Q4 |
| arlyear |
2021 |
| mrcbTft |
\nSoubory v repozitáři: lynnyk-0552998-kybernetika-licence.pdf |
| mrcbU14 |
SCOPUS |
| mrcbU24 |
PUBMED |
| mrcbU34 |
000752580600008 WOS |
| mrcbU56 |
článek odborném periodiku 3.509 kB |
| mrcbU63 |
cav_un_epca*0297163 Kybernetika 0023-5954 Roč. 57 č. 6 2021 1005 1018 Ústav teorie informace a automatizace AV ČR, v. v. i. |
|