| bibtype |
C -
Conference Paper (international conference)
|
| ARLID |
0568675 |
| utime |
20240402213621.3 |
| mtime |
20230216235959.9 |
| title
(primary) (eng) |
Bohl-Marek decomposition applied to a class of biochemical networks with conservation properties |
| specification |
| page_count |
4 s. |
| media_type |
E |
|
| serial |
| ARLID |
cav_un_epca*0568674 |
| ISBN |
978-80-86407-85-2 |
| title
|
Proceedings of the Seminar on Numerical Analysis & Winter School /SNA' 23/ |
| page_num |
56-59 |
| publisher |
| place |
Ostrava |
| name |
Institute of Geonics of the Czech Academy of Sciences |
| year |
2023 |
|
| editor |
|
| editor |
| name1 |
Sysala |
| name2 |
Stanislav |
|
| editor |
| name1 |
Sysalová |
| name2 |
Dagmar |
|
|
| keyword |
Mathematical modeling |
| keyword |
Biochemical network |
| keyword |
Pharmacokinetic (PBPK) models |
| author
(primary) |
| ARLID |
cav_un_auth*0404313 |
| name1 |
Papáček |
| name2 |
Štěpán |
| institution |
UTIA-B |
| full_dept (cz) |
Teorie řízení |
| full_dept (eng) |
Department of Control Theory |
| department (cz) |
TŘ |
| department (eng) |
TR |
| country |
CZ |
| fullinstit |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0100790 |
| name1 |
Matonoha |
| name2 |
Ctirad |
| institution |
UIVT-O |
| full_dept (cz) |
Oddělení výpočetní matematiky |
| full_dept |
Department of Computational Mathematics |
| full_dept |
Department of Computational Mathematics |
| fullinstit |
Ústav informatiky AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0208862 |
| name1 |
Duintjer Tebbens |
| name2 |
Jurjen |
| institution |
UIVT-O |
| full_dept (cz) |
Oddělení výpočetní matematiky |
| full_dept |
Department of Computational Mathematics |
| full_dept |
Department of Computational Mathematics |
| country |
NL |
| fullinstit |
Ústav informatiky AV ČR, v. v. i. |
|
| source |
|
| cas_special |
| project |
| project_id |
GA21-03689S |
| agency |
GA ČR |
| country |
CZ |
| ARLID |
cav_un_auth*0410139 |
|
| abstract
(eng) |
This study presents an application of one special technique, further called as Bohl-Marek decomposition, related to the mathematical modeling of biochemical networks with mass conservation properties. We continue in direction of papers devoted to inverse problems of parameter estimation for mathematical models describing the drug-induced enzyme production networks [3]. However, being aware of the complexity of general physiologically based pharmacokinetic (PBPK) models, here we focus on the case of enzyme-catalyzed reactions with a substrate transport chain [5]. Although our ultimate goal is to develop a reliable method for fitting the model parameters to given experimental data, here we study certain numerical issues within the framework of optimal experimental design [6]. Before starting an experiment on a real biochemical network, we formulate an optimization problem aiming to maximize the information content of the corresponding experiment. For the above-sketched optimization problem, the computational costs related to the two formulations of the same biochemical network, being (i) the classical formulation x˙(t) = Ax(t) + b(t) and (ii) the 'quasi-linear' Bohl-Marek formulation x˙M(t) = M(x(t)) xM(t), can be determined and compared. |
| action |
| ARLID |
cav_un_auth*0445278 |
| name |
SEMINAR ON NUMERICAL ANALYSIS - SNA'23 In memoriam of professor Radim Blaheta |
| dates |
20230123 |
| mrcbC20-s |
20230127 |
| place |
Ostrava |
| country |
CZ |
|
| RIV |
BC |
| FORD0 |
10000 |
| FORD1 |
10100 |
| FORD2 |
10102 |
| reportyear |
2024 |
| num_of_auth |
3 |
| mrcbC47 |
UIVT-O 10000 10100 10101 |
| presentation_type |
PO |
| inst_support |
RVO:67985556 |
| inst_support |
RVO:67985807 |
| permalink |
https://hdl.handle.net/11104/0339944 |
| cooperation |
| ARLID |
cav_un_auth*0445280 |
| name |
Faculty of Pharmacy, Charles University, Hradec Králové |
| country |
CZ |
|
| confidential |
S |
| arlyear |
2023 |
| mrcbU14 |
SCOPUS |
| mrcbU24 |
PUBMED |
| mrcbU34 |
WOS |
| mrcbU56 |
poster |
| mrcbU63 |
cav_un_epca*0568674 Proceedings of the Seminar on Numerical Analysis & Winter School /SNA' 23/ Institute of Geonics of the Czech Academy of Sciences 2023 Ostrava 56 59 978-80-86407-85-2 |
| mrcbU67 |
Starý Jiří 340 |
| mrcbU67 |
Sysala Stanislav 340 |
| mrcbU67 |
Sysalová Dagmar 340 |
|