| bibtype |
J -
Journal Article
|
| ARLID |
0597935 |
| utime |
20240905113248.8 |
| mtime |
20240905235959.9 |
| SCOPUS |
85198332961 |
| WOS |
001270312300001 |
| DOI |
10.1016/j.isci.2024.110451 |
| title
(primary) (eng) |
Spatio-temporal requirements of Aurora kinase A in mouse oocyte meiotic spindle building |
| specification |
| page_count |
15 s. |
| media_type |
E |
|
| serial |
| ARLID |
cav_un_epca*0497635 |
| ISSN |
iScience |
| title
|
iScience |
| volume_id |
27 |
| publisher |
|
|
| keyword |
Aurora kinase A |
| keyword |
mouse oocyte |
| keyword |
meiotic spindles |
| author
(primary) |
| ARLID |
cav_un_auth*0409371 |
| name1 |
Blengini |
| name2 |
C. S. |
| country |
US |
|
| author
|
| ARLID |
cav_un_auth*0356104 |
| name1 |
Vaškovičová |
| name2 |
Michaela |
| institution |
UZFG-Y |
| full_dept (cz) |
Laboratoř integrity DNA |
| full_dept |
Laboratory of DNA Integrity |
| department |
LID |
| full_dept |
Biomedical Research Team |
| country |
CZ |
| fullinstit |
Ústav živočišné fyziologie a genetiky AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0101190 |
| name1 |
Schier |
| name2 |
Jan |
| institution |
UTIA-B |
| full_dept (cz) |
Zpracování obrazové informace |
| full_dept |
Department of Image Processing |
| department (cz) |
ZOI |
| department |
ZOI |
| full_dept |
Department of Image Processing |
| fullinstit |
Ústav teorie informace a automatizace AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0329873 |
| name1 |
Drutovič |
| name2 |
Dávid |
| institution |
UZFG-Y |
| full_dept (cz) |
Laboratoř integrity DNA |
| full_dept |
Laboratory of DNA Integrity |
| department |
LID |
| full_dept |
Biomedical Research Team |
| country |
CZ |
| fullinstit |
Ústav živočišné fyziologie a genetiky AV ČR, v. v. i. |
|
| author
|
| ARLID |
cav_un_auth*0340757 |
| name1 |
Schindler |
| name2 |
K. |
| country |
US |
|
| source |
|
| cas_special |
| project |
| project_id |
GA23-07532S |
| agency |
GA ČR |
| country |
CZ |
| ARLID |
cav_un_auth*0458771 |
|
| abstract
(eng) |
Meiotic spindles are critical to ensure chromosome segregation during gamete formation. Oocytes lack centrosomes and use alternative microtubule-nucleation mechanisms for spindle building. How these mechanisms are regulated is still unknown. Aurora kinase A (AURKA) is essential for mouse oocyte meiosis because in pro-metaphase I it triggers microtubule organizing-center fragmentation and its expression compensates for the loss of the two other Aurora kinases (AURKB/AURKC). Although knockout mouse models were useful for foundational studies, AURK spatial and temporal functions are not yet resolved. We provide high-resolution analyses of AURKA/AURKC requirements during meiotic spindle-building and identify the subcellular populations that carry out these functions: 1) AURKA is required in early spindle assembly and later for spindle stability, whereas 2) AURKC is required in late pro-metaphase, and 3) Targeted AURKA constructs expressed in triple AURK knockout oocytes reveal that spindle pole-localized AURKA is the most important population controlling spindle building and stability mechanisms. |
| result_subspec |
WOS |
| FORD0 |
10000 |
| FORD1 |
10600 |
| FORD2 |
10605 |
| reportyear |
2025 |
| inst_support |
RVO:67985904 |
| inst_support |
RVO:67985556 |
| permalink |
https://hdl.handle.net/11104/0355715 |
| confidential |
S |
| contract |
| name |
CC BY-NC-ND license |
| note |
open access |
|
| article_num |
110451 |
| mrcbC91 |
A |
| mrcbT16-e |
MULTIDISCIPLINARYSCIENCES |
| mrcbT16-j |
1.499 |
| mrcbT16-D |
Q1 |
| arlyear |
2024 |
| mrcbU14 |
85198332961 SCOPUS |
| mrcbU24 |
39081293 PUBMED |
| mrcbU34 |
001270312300001 WOS |
| mrcbU63 |
cav_un_epca*0497635 iScience 2589-0042 Roč. 27 č. 8 2024 Cell Press ONLINE |
|